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Topical Vitamin B12: A Promising New Approach for Atopic Dermatitis

  • Saesha Loonker
  • May 31, 2024
  • 2 min read





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You probably know by now that I am interested in all and any research related to eczema. I came across this published paper which I found interesting and I feel can be a game changer for someone thinking of trying new and unconventional methods to help with their skin. I will cite this published article at the end of this post in case you want to go read in more directly from the source.


According to the study, significant superiority of vitamin B12 cream was discovered as compared to placebo in reducing the extent and severity of atopic dermatitis. This finding is groundbreaking for several reasons:

  1. Patients using vitamin B12 cream experienced a marked improvement in their AD symptoms. The cream effectively reduced the redness, itching, and inflammation that characterize this condition, offering much-needed relief to sufferers.

  2. Unlike some other treatments that can cause irritation or other side effects, vitamin B12 cream was very well tolerated by patients. This makes it a viable option for individuals with sensitive skin who might struggle with other medications.

  3. The studies on topical vitamin B12 have shown that it involves only very low safety risks for patients. This is particularly important for a condition like AD, which often requires long-term management strategies.


Vitamin B12, also known as cobalamin, plays a crucial role in the body's functioning, including skin health. Vitamin B12 has been shown to possess anti-inflammatory properties, which can help reduce the skin inflammation seen in AD. It is essential for cell regeneration and repair, which can promote healing in the damaged skin of AD patients. By improving skin barrier function, vitamin B12 cream may help prevent the penetration of allergens and irritants that can trigger AD flare-ups.


As discussed in previous posts, traditional treatments for atopic dermatitis, can be effective but often come with side effects, especially with long-term use. These can include skin thinning, increased risk of infections, and potential hormonal effects.

Vitamin B12 cream offers a promising alternative or complementary treatment with fewer risks:

  • As a non-steroidal option, vitamin B12 cream avoids the potential side effects associated with corticosteroids.

  • Patients report fewer side effects with vitamin B12 cream, making it a safer option for long-term use.

  • Incorporating vitamin B12 into the skincare regimen of AD patients provides a more holistic approach to treatment, focusing on overall skin health and repair.


The introduction of topical vitamin B12 as a treatment for atopic dermatitis represents a significant advancement in the management of this condition. Its ability to reduce symptoms effectively, combined with its excellent safety profile, makes it an exciting new option. As with any treatment, it’s important to consult with a healthcare provider to determine the best approach for managing atopic dermatitis. However, the promising results of vitamin B12 offer hope for many who suffer from this chronic skin condition. By incorporating this new therapeutic approach, patients may find greater relief and an improved quality of life.


M. Stücker, C. Pieck, C. Stoerb, R. Niedner, J. Hartung, P. Altmeyer, Topical vitamin B12—a new therapeutic approach in atopic dermatitis—evaluation of efficacy and tolerability in a randomized placebo‐controlled multicentre clinical trial, British Journal of Dermatology, Volume 150, Issue 5, 1 May 2004, Pages 977–983, https://doi.org/10.1111/j.1365-2133.2004.05866.x





 
 
 

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